Each month, the Office of Sponsored Programs will spotlight a different PI and their research. If you are interested in being featured in our next spotlight, please email firstname.lastname@example.org . Please be sure to provide us with an abstract (3-5 paragraphs) about your research, explanation of your recent project, the amount your project (s) were funded for, special events that you are hosting or coordinating, obstacles or challenges you faced during the application process, if applicable, and a photo of yourself .
Artem V. Domashevskiy, PhD
Assistant Professor, Department of Sciences
Dr. Artem Domashevskiy is Assistant Professor of Biochemistry and Molecular Biophysics at John Jay College of
Criminal Justice. Dr. Domashevskiy uses methods in molecular biology and biophysics to study structure, function, and properties of ribosome inactivating proteins (RIPs), e.g., pokeweed antiviral protein (PAP) isolated from Phytolacca americana plant, ricin toxin from castor bean plant, and others.
Dr. Domashevskiy recently received an Academic Research Enhancement Award (AREA) from the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID) in the amount of $445,387 for his project entitled “Development of a Novel Inhibitor of Ricin: A Potential Therapeutic Lead against Deadly Shiga and Related Toxins” for the period 01/02/2017– 2/31/2019.
This is a high-impact collaborative research project to develop new inhibitors for ribosome inactivating proteins
(RIPs), such as ricin and Shiga toxin. Ricin is a well-known homicidal poison and has been used in several bioterrorist attacks. Shiga toxin is a deadly product of enterobacterial Escherichia coli. There are no effective pharmaceuticals for either ricin or Shiga toxin poisoning. Dr. Domashevskiy proposes using a viral protein (VPg) from turnip mosaic virus that has shown to inhibit ricin activity in vitro. The goals of this research award are: 1) Establish conditions for VPg-ricin complex formation and the rates of VPg-ricin interactions; 2) Determine minimum VPg peptide that effectively inhibits ricin and Shiga toxins; and 3) Optimize conditions to enhance inhibition of these toxic proteins.This is an innovative activity. Based on the structural and mechanistic similarities of these toxins and previouslyacquired data showing that VPg peptides inhibit ricin activity in vitro, he believes the outcomes of this project will provide leads for the synthesis of therapeutic peptides. In turn, this will serve as a catalyst for the development of constructively applied solutions for the inhibition of these deadly toxins. Furthermore, this activity will enhance the infrastructure of research and education at John Jay College, introducing biochemical and biomedical research experiences to underrepresented minority and female students, who would otherwise lack such opportunities. This will allow them to experience a broad spectrum of techniques, and acquire skills such as data analysis used in modern scientific investigations, while developing a vast network of partnerships among scientists from national and international institutions.
Dr. Domashevskiy earned his PhD from the Graduate Center and Hunter College of the City University of New York.He is a recipient of the 2016 Henry Wasser Award from CUNY Academy for Humanities and Sciences, and is a member of the American Society for Biochemistry and Molecular Biology, American Society of Plant Biologists, New York Academy of Sciences, The RNA Society, Biophysical Society, and American Phytopathological Society. Dr. Domashevskiy has published in the Journal of Biological Chemistry, Toxins, Methods in Molecular Biology, the Journal of Nature and Science, and the Journal of Forensic, Legal & Investigative Sciences among others. Dr. Domashevskiy is also a PRISM mentor with the PRISM Program within John Jay’s Science Dept.